解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Ilex kudingcha C.J. Tseng (Kudingcha) is a traditional Chinese drink consumed in East Asia. The present study evaluated the in vitro anticancer effects of Kudingcha in MCF-7 human breast adenocarcinoma cells using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay. At a concentration of 200 μg/...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1253
更新日期:2013-05-01 00:00:00
abstract::The Notch signaling pathway has been shown to be involved in the progression of chronic myeloid leukemia (CML). The aim of this study was to investigate the effects of exogenous Notch2 overexpression on cell proliferation and possible mechanisms in the human CML cell line K562. When exogenous intracellular fragment of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1159
更新日期:2013-04-01 00:00:00
abstract::Approximately 34-86% of neoplasms of the salivary glands are located in the parotid gland and parotidectomy is the first-line treatment for parotid gland tumors. Frey syndrome and cosmetic deformity are common complications experienced by patients following parotidectomy and the sternocleidomastoid muscle flap (SCMF) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1179
更新日期:2013-04-01 00:00:00
abstract::Expression of the transcription factor hypoxiainducible factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia, particularly in relation to tumour angiogenesis. Expression of the HIF-1α subunit is responsive to changes in oxygen levels. Overexpression of HIF-1α has been reported to be associated with a po...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1185
更新日期:2013-04-01 00:00:00
abstract::We report a case of tumor lysis syndrome (TLS) in a patient with gallbladder carcinoma. TLS has not been reported in association with this type of tumor. TLS typically occurs in cases of highly proliferative hematological malignancies and small cell carcinoma. Two factors that may have contributed to TLS in this case ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1189
更新日期:2013-04-01 00:00:00
abstract::Gelatinases are overexpressed in several types of maligancies and tumor stromal cells. Lidamycin is an enediyne antitumor antibiotic, which is composed of an apoprotein (LDP) and an active chromophore (AE). It is known that the heavy-chain complementarity-determining region-3 (CDR3) domain of scFv is important in anti...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1143
更新日期:2013-04-01 00:00:00
abstract::Docetaxel is a well-known causative agent of nail alterations. The aim of this study was to reveal the impact of nail alterations associated with low-dose metronomic (LDM) docetaxel chemotherapy on the survival of non-small cell lung cancer (NSCLC) patients. Clinical information, survival data and nail alterations in ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1178
更新日期:2013-04-01 00:00:00
abstract::Pro-angiogenic factors [vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)] and anti-angiogenic factors (endostatin) play important roles in the progression of pancreatic cancer. The purpose of the present study was to investigate the knockdown effect by either VEGF or bFGF siRNA on th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1102
更新日期:2013-03-01 00:00:00
abstract::Our previous study demonstrated that the 2-benzyloxybenzaldehyde analog CCY-1a-E2 is a potent compound against HL-60 human leukemia cell lines. To investigate the potential therapeutic application of CCY-1a-E2 for leukemia, we analyzed the antileukemic effects and safety of CCY-1a-E2 in the BALB/c mouse WEHI-3 allogra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1079
更新日期:2013-03-01 00:00:00
abstract::Myelolipoma is a rare, benign neoplasm composed of mature adipocytes and hematopoietic tissue, mainly occurring in the adrenal glands. The majority of extra-adrenal myelolipomas have been identified in the presacral region and primary mediastinal myelolipoma is very rare. Computed tomography (CT) and magnetic resonanc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1085
更新日期:2013-03-01 00:00:00
abstract::Zinc finger E-box binding homeobox 1 (ZEB1) has been shown to promote invasion and metastasis in several types of human cancer and to have a prognostic role in certain cancers. However, the clinical significance of ZEB1 in colorectal cancer (CRC) has not been sufficiently investigated. This study aimed to address this...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1026
更新日期:2013-02-01 00:00:00
abstract::The issue of delayed neurological damage as a result of treatment is becoming increasingly important now that an increased number of children survive treatment for acute lymphoblastic leukemia (ALL). Following modification of the treatment protocols, severe symptomatic late effects are rare, and most adverse effects a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1072
更新日期:2013-02-01 00:00:00
abstract::Giant cell tumor (GCT) of the bone is a relatively common primary bone tumor. Treatment with simple curettage often results in a high local recurrence rate. Tumor resection and reconstruction with prosthesis or an allograft has a low rate of local recurrence; however, the patient's native joint function becomes signif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1036
更新日期:2013-02-01 00:00:00
abstract::Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase ch...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1052
更新日期:2013-02-01 00:00:00
abstract::Autophagy is a lysosomal degradation process which is key for the regulation of the turnover of long-lived or damaged proteins and organelles and which promotes cell survival during nutrient deprivation or other microenvironmental stresses. Current evidence supports the hypothesis that autophagy suppresses tumorigenes...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1015
更新日期:2013-02-01 00:00:00
abstract::C-X-C chemokine receptor types 1/2 (CXCR1/2) may play multiple roles in the development and progression of a number of types of tumor. The abnormal expression of CXCR1/2 in various types of malignant tumors has been reported, but less is known with regard to gastric carcinoma. The present study was preliminarily condu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1043
更新日期:2013-02-01 00:00:00
abstract::The histological boundary between benign and malignant vascular tumors is not clear. Thus, the discrepancies between clinical judgement and pathological diagnosis often lead to a difficult clinical decision, and may result in misdiagnosis. In order to develop more effective treatment methods, the clinical and patholog...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1025
更新日期:2013-02-01 00:00:00
abstract::Gastric cancer and cholangiocarcinoma are problematic throughout the world due to their destructive malignancy. In attempts to treat cholangiocarcinoma and gastric cancer, researchers often explore the effects of transforming growth factor-β1 (TGF-β1). TGF-β1 plays a crucial role in causing cell cycle arrest and fibro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1024
更新日期:2013-02-01 00:00:00
abstract::The aim of this study was to evaluate the efficacy of multi-detector row helical computed tomography (MDCT) angiography in the detection of feeding arteries prior to multi-arterial infusion for lung cancer. A total of 59 consecutive patients (44 males and 15 females; age range, 27-86 years; median age, 62 years) with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1000
更新日期:2013-01-01 00:00:00
abstract::Platinum-compound chemotherapy is known to have ototoxic side-effects. However, there is a paucity of literature examining hearing function prospectively and longitudinally in cohorts containing paediatric and adult patients treated within the same cisplatin- or carboplatin-containing treatment trial protocols. In Ger...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.997
更新日期:2013-01-01 00:00:00
abstract::In colorectal cancer (CRC), KRAS and BRAF mutations in primary tumors are associated with resistance to anti-epidermal growth factor receptor (anti-EGFR)-based therapies. However, the correlation between KRAS/BRAF mutation in primary tumors and serum has not been well studied. To evaluate the degree of concordance of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.963
更新日期:2013-01-01 00:00:00
abstract::Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Recent studies have shown that extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) promotes adhesion, invasion and metastasis of malignant tumor cells. The aim of this study was to investigate the impact of EMMPRIN/CD1...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.981
更新日期:2013-01-01 00:00:00
abstract::Carcinogenesis is characterized by an abnormal regulation of the cell cycle. Regulators of the cell cycle such as cyclin E play an important role in neoplasia and may be correlated with prognosis. The clinical significance of the expression of cyclin E in stage III colorectal carcinoma has not yet been investigated. T...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.955
更新日期:2013-01-01 00:00:00
abstract::Cancer immunotherapies are designed to elicit T-cell responses that inhibit tumor growth. Previous studies have demonstrated that interleukin 21 (IL-21) is a promising cytokine for cancer immunotherapy due to its ability to induce the immunity of T cells and natural killer cells, whereas blockade of the interaction of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.966
更新日期:2013-01-01 00:00:00
abstract::DNA hypomethylation is associated with carcinogenesis due to its involvement in cancer initiation and progression. In this study we analyzed the hypomethylation status of candidate genes in clear cell renal cell carcinoma (CCRCC) using a large-scale, high-throughput DNA methylation profiling technique. Results reveale...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.992
更新日期:2013-01-01 00:00:00
abstract::We experienced a rare case of primary intracranial choriocarcinoma treated successfully with synchronous chemotherapy and radiotherapy followed by three consecutive courses of chemotherapy without surgery. A 19-year-old male patient presented with a two-week history of diplopia, headache, nausea and vomiting. Neurolog...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.901
更新日期:2012-12-01 00:00:00
abstract::Low-grade glioma is predisposed to progress to anaplastic astrocytoma and eventually secondary glioblastoma. The malignant transformation may involve the accumulation of multiple genetic alterations. The purpose of this study was to explore the role of miR-544 in glioma progression and discuss whether it may be a nove...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.918
更新日期:2012-12-01 00:00:00
abstract::The phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway is a cellular pathway involved in cell growth, tumorigenesis and cell invasion which is frequently activated in various types of cancer. The downstream effector of the pathway is mTOR which is important in cellular growth and homeost...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.930
更新日期:2012-12-01 00:00:00
abstract::Recommendations concerning the intake of vitamin D and/or sunlight exposure in the handling of patients with vitamin D deficiency remain a matter of debate. The present study of the German network of dermato-oncologists (Onkoderm e.V.) refers to an inquiry conducted among general practitioners on this and related issu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.939
更新日期:2012-12-01 00:00:00
abstract::Clear cell myoepithelial carcinoma is a very rare disease which develops primarily in the parotid gland. To date, only 17 cases of clear cell myoepithelial carcinoma have been reported worldwide. Among them, only three cases developed in the minor salivary gland in the oral cavity. No cases developed in the base of th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.900
更新日期:2012-12-01 00:00:00
abstract::In our previous study, we demonstrated that type II cGMP-dependent protein kinase (PKG II) was expressed at lower levels in different human cancer cell lines and that exogenous PKG II inhibited epidermal growth factor (EGF)-induced MAPK/ERK signaling. In order to investigate its functions further in this signaling pat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.851
更新日期:2012-11-01 00:00:00
abstract::The aim of this study was to investigate the predictive impact of polymorphisms in the HIF-1α gene on the response to chemoradiotherapy (CRT) in rectal cancer. This study included two cohorts of patients with locally advanced rectal cancer receiving long-course CRT. The HIF-1α C1772T (rs11549465), G1790A (rs11549467) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.837
更新日期:2012-11-01 00:00:00
abstract::Connexins (Cxs), a conserved family of trans-membrane proteins, function in the organization of cell-cell communicatin via gap junctions in multicellular organisms. However, the role of Cxs in acute myeloid leukemia (AML) is poorly understood. In this study, we investigated the relationship between cell proliferation ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.884
更新日期:2012-11-01 00:00:00
abstract::Synovial sarcoma (SS) is a soft tissue sarcoma of unknown histogenesis that rarely occurs in the female genital tract. We report a case of SS occurring in the right vulva of a young Japanese female. The tumor was composed of poorly differentiated rounded cell areas, surrounded by fibroblastic spindle-shaped cell areas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.857
更新日期:2012-11-01 00:00:00
abstract::Some colorectal cancer liver metastases (CLMs) disappear on serial imaging during chemotherapy and the optimal treatment strategy for such lesions remains undetermined. The purpose of this study was to investigate the outcome in disappearing CLMs, as few studies have focused on this topic, with conflicting results. Am...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.842
更新日期:2012-11-01 00:00:00
abstract::The aim of the current study was to investigate the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) expression and cell proliferation in the human osteosarcoma cell line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 and 40 μmol/l) for various times (24, 48 and 72...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.824
更新日期:2012-10-01 00:00:00
abstract::The aim of this study was to investigate the correlation between H-ras mutation and primary hepatocellular carcinoma (HCC) and to describe the role of H-ras mutation in carcinogenesis. Clinical samples of 69 patients were collected and the expression levels of H-ras in HCC and the surrounding normal tissues were exami...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.832
更新日期:2012-10-01 00:00:00
abstract::5-fluorouracil (5-FU) is one of the standard chemoradiotherapy regimens for hepatocellular carcinoma (HCC) treatment. B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) has been demonstrated to regulate proliferation. Additionally, Bmi-1 overexpression has been identified in HCC cell lines and corr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.805
更新日期:2012-10-01 00:00:00
abstract::Non-steroidal nuclear receptors play a major role in breast cancer development. A correlation among, and possible prognostic function of, the members of the nuclear receptor superfamily has been discussed controversially over the years. Hence, we conducted a quantification of the different expression levels of the thy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.799
更新日期:2012-10-01 00:00:00
abstract::The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistoch...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.814
更新日期:2012-10-01 00:00:00